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KMID : 1189220090360030199
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Korean Journal of Reproductive Medicine
2009 Volume.36 No. 3 p.199 ~ p.207
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Expression of Decidual Natural Killer (NK) Cells in Recurrent Abortion Patients with Increased Peripheral NK cells
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Lee Hyun-Joo
Kim Sun-Haeng
Yang Kwang-Moon
Park Dong-Wook
Park Chan-Woo
Hong Sung-Ran
Cho Dong-Hee
Song In-Ok
Koong Mi-Kyoung
Kang Inn-Soo
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Abstract
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Objectives : The purpose of this study was to compare the decidual NK cell populations between increased pre-conceptional peripheral NK cell population and normal pre-conceptional peripheral NK cell population in women with a history of recurrent abortion.
Methods : Fourteen women with history of recurrent abortion and elevated pre-conceptional peripheral NK cell, above 15% of peripheral lymphocyte population were included in this study. As a control, twelve women with history of recurrent abortion and their peripheral NK cell percentage showed below 15% were included. Distribution of CD56+ and CD16+NK cells in paraffin embedded decidual tissues including implantation sites were examined by immunohistochemical staining using anti-CD56, 16 monoclonal antibodies. After immuohistochemical staining, the numbers of NK cells were counted and compared these results between study and control groups.
Results : There was significant difference in decidual CD56+NK cell count (170.1±132.1 vs. 68.3±66.1, p=0.02) between increased peripheral CD56+NK cell group and control group. But, there showed no statistically significant correlation between decidual CD56+NK cell count and peripheral CD56+NK cell percentage.(r=0.229, p=0.261) Also there was no statistically difference decidual CD16+NK cell count between study and control group (25.70±11.72 vs. 31.17±22.67), and no correlation between decidual CD16+NK cell and peripheral CD16+NK cell percentage. (r=-1.40, p=0.535)
Conclusions : This study shows that decidual CD56+NK cell are significantly increased in decidua of women exhibiting a history of recurrent abortion with increased CD56+ peripheral NK cell. This study suggests that the percentage of peripheral NK cell reflect the expression of decidual NK cell. Consequently, pre-conceptional peripheral blood NK cell population can be the useful marker for detecting the risk of subsequent miscarriage.
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KEYWORD
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peripheral CD56+ NK cell, decidual CD56+ NK cell, recurrent abortion
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